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The Wound Healing Continuum — From Chronic to Acute

Speaker: Matthew Regulski, DPM

Lower extremity wounds, such as diabetic foot ulcers and venous ulcers, are more prone to issues of chronicity and recurrence due to factors such as peripheral arterial disease, diabetes, and increased infection rates. Wound care clinicians are familiar with the standard of care in wound management including good wound bed preparation and moisture management, but sometimes, especially in complex lower extremity wounds, these strategies aren’t enough to achieve wound closure.

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Therapeutic Interventions for Complex, Chronic Wounds

This useful guide to the treatment of complex, chronic wounds first discusses risk factors that predispose patients to the development of these wounds, as well as comorbidities and other conditions that complicate healing. The guide then describes the latest evidence-based advanced interventions for the treatment of complex, chronic wounds.


Quick Facts – Complex Wound Management

This fact sheet covers the latest information on managing chronic complex wounds. The print-friendly format is perfect for posting on the bulletin board or distributing to your nursing staff at in-service.


How Growth Factors Support Wound Healing

Growth factors and cytokines are secreted by the cells and are essential to the complex wound healing and tissue regeneration process. This process involves the interplay of growth factors with chemokines…

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Chronicity in Lower Extremity Wounds

Chronic wounds of the lower extremities impose an increasing burden on health care providers and systems, and they can have a devastating impact on patients and their families. These wounds include diabetic ulcers, venous ulcers, arterial ulcers…

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Preventing Recurrent Lower Extremity Wounds

Chronic and complex wounds of the lower extremity frequently recur. It is difficult to determine the precise recurrence rate across patients with different lower extremity wound types, including diabetic…

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Advanced Wound Care Interventions for Non-Healing Wounds

Chronic and non-healing wounds are those that do not progress through the healing process in a timely or predicted manner. They are a global problem and are becoming harder to treat. Medicare…

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How Much Do You Know Complex Wounds?

Take our 10-question quiz to find out.

Terms to Know: Complex Wound Management

Angiogenesis: The complex process in which the growth of normal, stable, and functional vessels is critically dependent on the coordinated interplay in space and time of different cell types and growth factors. This process involves the forming of new blood vessels from preexisting vessels by invading the wound clot to organize in a microvascular network throughout granulation tissue.

Autologous cell therapy: A therapeutic intervention that uses an individual’s cells, which are cultured and expanded outside of the body and reintroduced into the donor as a bioengineered skin substitute to aid in wound closure.

Immunomodulation: Therapeutic interventions aimed at modifying the immune response. Healing in chronic and complex wounds can be enhanced with immunomodulating agents.

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