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The Wound Microbiome:

Striking a Bacterial Balance

Clinicians aim for the perfect healing cascade to wound closure. However, inconsistencies in the wound healing continuum impair healing as a result of significant factors such as biofilm formation and infection. This illustrated guide provides background information on the composition and mechanisms of biofilms and their role in wound chronicity and infection.


Chronic Wounds and Biofilms:

Advancing Assessment and Treatment

Normal healing of acute skin wounds proceeds through the four sequential phases of hemostasis, inflammation, repair, and remodeling. However, if contaminating planktonic bacteria are able to proliferate and generate biofilm communities, it leads to chronic inflammation that produces persistently elevated levels of proteases and reactive oxygen species that destroy proteins that are essential for healing (extracellular matrix, growth factors, receptors) eventually leading to a stalled, chronic wound.

Quick Facts – Wound Biofilms

Download Quick Facts – Wound Biofilms and share it within your facility. This two-page fact sheet was created to support staff education on biofilm and its role in wound infection. The print-friendly format is perfect for posting on the bulletin board or distributing to your nursing staff at in-service.

How Much Do You Know About Biofilm Management?

How much do you know about wound biofilm management?
Take our 10-question quiz to find out!

Terms to know: Wound Biofilm Management

Aerobic microorganisms: Organisms thriving in an oxygen-rich environment.

Anaerobic microorganisms: Organisms thriving in an oxygen-depleted environment.

Autolytic debridement: A selective process by which endogenous phagocytic cells and proteolytic enzymes break down necrotic tissue…


The Skin Microbiome: Factors Related to Wound Chronicity

The human skin microbiome is incredibly diverse and can contain up to one billion microorganisms on a single square centimeter, including bacteria, fungi, viruses, and arthropods. These dynamic…

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Understanding the Wound Infection Continuum

Wound infection is a complex process that can be affected by a variety of factors, some of which inhibit the ability to heal. The first stage of healing, the inflammatory stage, is particularly susceptible to chronicity…

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Wound Biofilm Development and Virulence

Wound biofilms not only impede healing but also increase the risk of infection. It is essential that wound biofilms be addressed and treated in a prompt, consistent manner. Biofilms have been an ongoing challenge…

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Breaking the Biofilm Cycle: Strategies for Evaluating and Managing Wound Bioburden

Advancements in molecular microbiology, microscopy technology, and techniques for study of bacteria have increased the ability to identify the existence of biofilms, but…

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January Practice Accelerator Overview: Biofilms Across the Continuum

Wound chronicity is a major concern for clinicians, who must find the missing pieces of the puzzle for timely wound healing.

Watch this brief overview video to learn more about biofilms in wound care and the educational resources made available in the January Practice Accelerator portal on Wound Biofilms.

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